Peregrino-
Check out these videos for some VERY specific presentations on the coagulation pathways and how they relate to administration of factor VIIa. Note: If you haven't already had physiology and some medical training these videos aren't for you.
trauma surgeon's perspective:
http://www.bloodline.net/stories/storyReader$3107
http://www.bloodline.net/stories/storyReader$3108
hematology researcher's perspective:
http://www.bloodline.net/stories/storyReader$3103
IMO, from reviewing this information, it isn't very reasonable to carry "on you". Having it in a trauma surgeon's tool bag in a nearby field trauma hospital might be nice though depending on your injuries.
Your plavix and Asa 81mg treatments both work to decrease initial platelet aggregation at the site. I don't see how factor VIIa would do much to "reverse" the complications from taking these meds. At best, it would help mitigate the effects by increasing other pathways involved in hemostasis after a
major trauma.
FWIW, Factor VIIa does seem to have an important potential in advanced trauma management when treating patients who have had massive fluid resuscitation attempts as part of their management in the intial stabilization process. THAT seems to me very pertinant to this particular forum... maybe we can discuss this aspect and flush it out further. Perhaps this factor VIIa could be given at the initial triage facility(ex. base camp) and prevent the coagulopathy sometimes encountered after stabilization from beginning and provide less chance of subsequent complications.
Of course, for me to do this I would have to review all my old physiology info and combine it with what is discussed in the recent literature on this factor VIIa. Swatsurgeon or Doc T might be able to discuss in detail without having to dredge it up as they deal with these type issues daily.
