I am not familiar with this Journal, but maybe this helps:
Canadian Medical Association Journal
Quote:
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Individuals express CYP3A4 in different proportions, those with the highest intestinal concentration being most susceptible to grapefruit juice–drug interactions. An effect is seen with the whole fruit as well as its juice, so caution should be exercised with both. The precise chemical compound in grapefruit that causes the interaction has not been identified. There is no similar reaction with orange juice, although there is some suspicion that "sour oranges" such as the Seville variety, may have some effect.A recent study, however, that tested the known interference of grapefruit juice with cyclosporine showed no similar effect with Seville oranges.
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my bottom line:
-a small amount of grapefruit juice is enough to cause a significant drug interaction with certain drugs
-the effect can last 24 hours after drinking the Grapefruit Juice
-Oranges and other citrus are probably safe
-Someone discovered the Grapefruit/drug effect 16 years ago, yet nobody knows what the precise chemical compound is!!!