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As a hematologist, I rarely see acute CO poisoning - the ED docs may have an equation to share with you. I do not, but I could see why one would need to incorporate hemoglobin level (and carrying capacity, espcially in the setting of hemoglobinopathies) into any treatment algorithm.
The other wild card is duration of both anemia and CO exposure - if both are chronic, the body will likely have compensated (to some extent) to both.
One thing to keep in mind is that if a patient is symptomatic and sufficiently anemic, a pRBC transfusion could be therapeutic against both CO poisoning and anemia, provided there is no ongoing CO exposure.
I've not seen a lot of strong data that hyperbaric O2 is more effective than high flow atmospheric O2 in this setting either - but I'd love to see any new publications on this topic.
Good luck on you search and please share what you learn!
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"The dignity of man is not shattered in a single blow, but slowly softened, bent, and eventually neutered. Men are seldom forced to act, but are constantly restrained from acting. Such power does not destroy outright, but prevents genuine existence. It does not tyrannize immediately, but it dampens, weakens, and ultimately suffocates, until the entire population is reduced to nothing better than a flock of timid, uninspired animals, of which the government is shepherd." - Alexis de Tocqueville
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