Quote:
Originally Posted by Razor
No, not at all. I had never even heard of inflammasomes until now, so I truly appreciate the education. I'm assuming, using a HS-level understanding of cell function, that the nucleus has at least a degree of control over these inflammasomes, or are they independent actors?
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Sorry it took so long to get back to answering your question. The short answer is Yes but there is feedback - one regulating the other. I've attached a pretty good paper by one of the leaders in the field.
We can follow up with a discussion of how HFCS (or high doses of glucose) are stressors that effect the gut microbiota and that is what promotes obesity. HFCS is just a more concentrated form of fructose and in the continual levels we are ingesting them induce the change in the gut microbiota via the inflammasome. I suspect that fructose is more potent at inducing this effect than glucose, but haven't done the critical experiments to prove that point yet.
Hope this helps. More later.