My wife carries a .38 SPL LCR and also has a .22 LCR. She uses them both a lot. Three diamondback 'rattlers can attest to that.
The .22 was sensitive to certain brands of ammo at first, but, after about 100 rounds, it's running smooth now.
ETA: I had suggested that she get the .357/.38 but they didn't have one in stock. After firing her's, it's very light and the .357 might be too much to handle.
Pat