Professional Soldiers ® - View Single Post - Plavix & PPI May Contribute to Heart Attack

shr7 · 03-31-2010, 10:21

Bringing back an older thread here. Some updated data on the PPI and Plavix front.

PPIs May Help Reduce Hospitalizations for Gastroduodenal Bleeding in Patients Treated With Clopidogrel

http://www.medscape.com/viewarticle/718910

In an accompanying editorial, it is stated that this study provides a "counterpoint" to previous studies investigating co-prescription of Plavix and PPIs. Not sure if I agree. If memory serves right, in previous studies Protonix was considered one of the drugs least likely to interact while Prilosec was one of the most likely. In this study, Protonix accounted for 62% of the PPIs used and Prilosec only 9%.

I do like that the study investigates other causes of morbidity that just the cardiovascular endpoints. It helps to define the benefit in the risk-benefit analysis for using these medications. So, as before, I suppose we will just have to wait and see.

SR

03-31-2010, 10:21	#10
shr7 Asset Join Date: Dec 2007 Location: Pittsburgh PA Posts: 50	Bringing back an older thread here. Some updated data on the PPI and Plavix front. PPIs May Help Reduce Hospitalizations for Gastroduodenal Bleeding in Patients Treated With Clopidogrel http://www.medscape.com/viewarticle/718910 In an accompanying editorial, it is stated that this study provides a "counterpoint" to previous studies investigating co-prescription of Plavix and PPIs. Not sure if I agree. If memory serves right, in previous studies Protonix was considered one of the drugs least likely to interact while Prilosec was one of the most likely. In this study, Protonix accounted for 62% of the PPIs used and Prilosec only 9%. I do like that the study investigates other causes of morbidity that just the cardiovascular endpoints. It helps to define the benefit in the risk-benefit analysis for using these medications. So, as before, I suppose we will just have to wait and see. SR
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