I have an ankle holster, but experience and horror stories have gotten me away from ever using it on duty. Also agree that it will never be comfortable with a large frame automatic. Mine is a Blackhawk, I chose it because it's a bottom draw--I figured the chances of me being able to pull my pants leg up high enough to draw my weapon weren't very good in an "oh shit" situation on the ground, when I wasn't going to be able to get an effective shot off. Yes, it was weird knowing that there was nothing more than a strap causing it to defy gravity, but that was the trade off. I've gone to a vest holster now, and second the off-duty recommendation of a pants or pocket holster.
Or you could just stick it in your purse like me
. It has its own little compartment with dual access and everything.
Blackhawk holster