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I've seen it done on purpose, i.e. admin without prior exposure. I seem to remember 1-3 doses being used in the trial. Physostigmine was given as an antidote in the cohorts that drew the largest doses. I recall agitation after a single dose, but nothing incapacitating. Back in the day the protocol was to give up to three doses until the symptoms improved.
I've also seen injectors used incorrectly/backwards on purpose, driving the needle through the palm. You need to really screw up to do this -- if you correctly hold the injector like a pencil nothing untoward occurs if you try to deploy the wrong end.
This was all published somewhere back in the mid 80s -- Johns Hopkins 1984?
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